TRF1 Mediates Mitotic Abnormalities Induced by Aurora-A Overexpression
نویسندگان
چکیده
منابع مشابه
TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.
Aurora-A, a conserved serine-threonine kinase, plays essential roles in mitosis. Aberrant upregulation of Aurora-A perturbs proper mitotic progression and results in a generation of multinucleated cells with centrosome amplification. The molecular mechanisms for these mitotic defects remain elusive. Here, we show that the overexpressed Aurora-A-induced mitotic defects depend on the telomeric pr...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2010
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-09-2008